Longevity Companies

Mitochondrial quality control. OPA1-OMA1 pathway

Berkeley, CA

mTORC1 inhibitors

Berkeley, CA

Young blood factors or drugs targeting these factors

San Carlos, CA

new biotechnology company focused on cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine

Redwood City, CA

AMPK activator for cardiometabolic and age-related disease

New York, NY

Lifespan extension for companion animals. Life Biosciences portfolio company

Boston, MA

Clearing pathological cells with immunotherapy modalities

San Carlos, CA

Senotherapeutic that blocks transition from quiescence to senescence.

San Carlos, CA

proteostasis regulation, proteasome

Berlin, MA

Small molecules to break extracellular matrix crosslinks or prevent negative effects of crosslinks

Sherman Oaks, CA

Targeting TGF-beta family to treat a variety of diseases

Sudbury, MA

Diversified company building R&D platform, targeting multiple hallmarks of aging.

New York, NY

Modulating lysosome ion channels to improve autophagy

Cambridge, MA

Drugs that stimulate autophagy

Cambridge, MA

large scale screening for novel rejuvenation genes

Cambridge

Mitochondrial-derived peptides to treat metabolic and other diseases

Menlo Park, CA

Mitochondrial uncoupler to treat NASH, obesity

Blacksburg, VA

Cyclodextrin drugs to block 7-ketocholesterol to treat heart disease. Formerly Underdog Pharma

Novato, CA

Proteostasis enhancement and integrated stress response mimetics. Cambrian Biopharma portfolio company

New York, NY

Immunotherapy to remove senescent cells

San Francisco, CA

Restore lysosomal functions to treat neurodegenerative diseases

South San Francisco, CA

Senoblocker for CAR-T cell expansion

San Carlos, CA

Reversing calcification of tissues

Greenville, SC

GDF11 "young blood" factor

Newton, MA

Nicotinamide ribosome + pterostilbene. NAD+ booster

New York, NY

Device based filtering and modifying of cerebrospinal fluid to treat neurodegenerative disease.

Newburyport, MA

Cocoa analog to stimulate mitochondrial biogenesis

San Diego, CA

Mitochondrial uncoupler to treat obesity

San Francisco, CA

Nanoparticle delivered senolytic (fisetin)

Palo Alto, CA

Evvia is targeting mitochondrial dysfunction to create disease modifying treatments for devastating diseases, including Parkinson's and Alzheimer's diseases. small molecule activators for mitochondrial dysfunction (AMPK

Belmont, CA

FOXO4-p53 senenolytic

LaFayette, NY

SIRT6 activators for DNA repair

Cambridge, MA

Therapies to treat menopause and reproductive aging. Reprogramming to make ovarian cells

Austin, TX

Drugs that protect against LINE transposon

Buffalo, NY

Peptide discovery platform to treat neurodegenerative disease (in silico)

Newton, MA

Drugs that modulate immune system, inflaming, and cellular senescence

Miramar, FL

Vertically integrated longevity biotechnology company and CRO.

LaFayette, NY

epigenetic reprogramming to rejuvenate / regenerate optic nerve

Boston, MA

Neutral blood exchange to rejuvenate tissues.

Mountain View, CA

Reversing thyme involution with a combination of therapies

Torrance, CA

targeting transglutaminase 2 (TG2) to remove crosslinks and treat fibrosis

Brooklyn, NY

Reversing age-related decline of fertility

Coogee, MA

Transcription factors to reverse diseases of aging

San Francisco, CA

Holding company with stakes in 10+ longevity assets/companies

Ramsey

Removing Advanced Glycation End-products (AGE) crosslinks.

Syracuse, NY

Medical device to restore cerebrospinal fluid flow across the cribriform plate.

Riverside, CA

DisCo

Boston, MA

Longaevus Technologies is a private research organisation based in Cambridge, UK that explores new and diverse pathways to healthy longevity.

London

Peptide/small molecule drugs for Parkinson's and diabetes

Philadelphia, PA

Dog life extension. IGF pathway

San Francisco, CA

Using bacterial enzymes to break down lipofuscin (waste that cannot be degraded by lysosomes)

LaFayette, NY

Rejuvenation genes and reprogramming with applications in skin

Boston, MA

Matter Bioworks is a longevity holding company focused on preserving genome integrity. Assets include Spellcheck Bio, MutagenTech, and Loki Therapeutics

Brooklyn, NY

Mitochondrial targeted therapeutics for rare disease and aging.

Cambridge, MA

Mitophagy drugs. PINK1 Parkin pathway

San Francisco, CA

Whole body mitochondrial transfer

Pleasanton, CA

Rejuvenating hematopoietic stem cells by inhibiting Cdc42

Cincinnati, OH

oral TNF-1 inhibitor to target inflammaging

New York, NY

Artificial nano-scavengers capable of depleting specific signalling molecules in blood.

Mill Valley, CA

Drug that increases NAD+ levels

mTORC1 inhibitors and activators

Cambridge, MA

Epigenetic reprogramming

South San Francisco, CA

Natural compounds that activate sirt1 and sirt3 to treat metabolic disease

Harpers Ferry, WV

Gene therapy senolytic. Lipid protein nanoparticle

Seattle, WA

Senolytic peptide for cosmetic and therapeutic use.

San Francisco, CA

Anti-Mullerian Hormone therapeutics targeting ovarian aging.

New York, NY

Enhanced version of metformin. Target ion channel in complex I

San Francisco, CA

Maker of Rejuvant Life Tabs, a calcium alpha-ketoglutarate supplement

Fernandina Beach, FL

Targeting mitochondria genome, mtDNA express, and mitochondria quality control.

Waltham, MA

drugging FOXO transcription factor

Cologne

Gene therapies to extend lifespan of dogs

San Diego, CA

combination drug therapy to treat sarcopenia

Diepenbeek

mRNA hTERT (telomerase)

Mountain View, CA

Multi-asset umbrella longevity company

Schlieren

Gene therapy for heart disease and thyme involution

Syracuse, NY

drug discovery for blood brain barrier repair, neurodegenerative disease using organoid model

Emeryville, CA

Defunct. mTORC1 pathway. Merged with Adicet. Programs discontinued.

Boston, MA

Single therapy for multiple age-related diseases

San Francisco, CA

Deuterated polyunsaturated fatty acids to protect against lipid peroxidation

Los Altos, CA

Enzymes that degrade glucosepane crosslink.

San Francisco, CA

Cognition enhancing drugs that target the CREB and nitric oxide pathways to treat CNS conditions including Alz, anxiety.

Durham, NC

NAD+ pathway regulator for muscle aging

Houston, TX

Ablation of senescent cells and other pathological cells. Targeted prodrug approach?

Sunnyvale, CA

Muscle regeneration. Drugs that target the latent form of my-statin.

Cambridge, MA

Ketone-based therapies for heart disease

Drugs that activate chaperone-mediated autophagy

Boston, MA

Monoclonal antibody that targets a glycation marker of senescence

Chicago, IL

Elamipretide peptide to stabilize cardiolipin and reduce peroxidation

Needham, MA

Telomerase gene therapy for Alzheimer's disease.

Grand Rapids, MI

Telovance protein to enhance cell expansion

New York, NY

small molecule regeneration of thymus

St. Petersburg, FL

mTOR inhibitors

Epigenetic reprogramming with mRNA.

Mountain View, CA

Senolytics. Bcl-xL pathway and others

South San Francisco, CA

Drugs to modulate mitophagy to treat disease. USP inhibitors

Cambridge, MA

drug discovery platform company developing the next generation of induced-proximity medicine

San Francisco, CA

Cellular reprogramming

Drugs to reverse wrinkles and fair loss. Reversible mtDNA mutation mouse

Birmingham, AL

Young blood factors

Mountain View, CA

PAI-1 / apelin pathway for lifespan extension.

Los Angeles, CA

NAD+ boosting drugs

Cambridge, MA